![]() ![]() ![]() A blood sample should usually be taken 4–6 hours after an oral dose of a modified-release preparation.Negotiating a 25 price reduction with both LAMA+LABA products would lead to a small reduction in OPDP expenditure (approximately 2.5 million annually). Plasma-theophylline concentration should be measured 5 days after starting oral treatment and at least 3 days after any dose adjustment. number of units of LAMA+LABA products was based on previous use of LAMA and ICS+LABA products forecasted a smaller budget increase of less than 1.Recommended blood monitoring on initiation of theophylline when required:.Patients with good control (ACT>20 / CAT 225mg twice a day), or medications that can affect blood levels, or currently have active level monitoring, will require blood level monitoring if switched to theophylline.NHS Lanarkshire Respiratory Team advice (February 2021): For information relating to interactions see BNF for details.ĭiscontinuation of aminophylline (Phyllocontin ®) tablets Theophylline has a narrow margin between therapeutic and toxic effects therapy should be monitored.LONG ACTING MUSCARINIC ANTAGONISTS & LONG ACTING BETA AGONISTS (LAMA/LABA). Intravenous aminophylline is not a recommended drug in primary care having been superseded by nebulised beta 2–agonists. BRAND: ALL INHALERS TO BE PRESCRIBED BY BRAND ESPECIALLY COMBINATION INHALERS.Prescribing by brand is recommended for oral formulations due to variations in bioavailability.See below for advice on further management of patients currently prescribed Phyllocontin ® products.Please note - aminophylline preparations Phyllocontin ® Continus 225mg and Phyllocontin ® Forte Continus 350mg tablets have been discontinued ( MHRA Central Alerting System Feb 2021). ![]()
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